Polyglutamines Stop Traffic
نویسندگان
چکیده
منابع مشابه
Polyglutamines Stop Traffic Axonal Transport as a Common Target in Neurodegenerative Diseases
In this issue of Neuron, two papers provide evidence that polyglutamine (polyQ) proteins disrupt axonal transport. Gunawardena et al. show that normal levels of huntingtin are required for proper axonal transport in Drosophila. In addition, expression of expanded polyQ proteins disrupts axonal transport in larval neurons. Szebenyi and colleagues find that polyQ proteins directly inhibit fast ax...
متن کاملPolyglutamines Placed into Context
Nine inherited neurodegenerative disorders result from polyglutamine expansions. Two recently published papers on spinocerebellar ataxia type 1, together with studies on spinobulbar muscular atrophy last year, indicate that host protein context is the key arbiter of polyglutamine disease protein toxicity. This insight may represent the most important development in the field since the recogniti...
متن کاملOn Stop-and-Go Waves in Dense Traffic
From a Vlasov-type kinetic equation with nonlocal braking and acceleration forces, taken as a traffic model for higher densities, we derive macroscopic equations generalizing the second order model of conservation laws suggested by Aw and Rascle [1] and Zhang [2]. The nonlocality remains present in these equations, but more conventional, local equations are derived by using suitable Taylor expa...
متن کاملFast Stereo based Object Detection for Stop&Go Traffic
This paper presents a new fast binocular stereo approach for the detection and tracking of objects, in particular for stop&go traffic. The proposed scheme is based on a local feature extraction and detects dominant objects by means of a Hough transform like disparity grouping. It is able to handle not only vehicles, but also other objects such as pedestrians. In addition, it allows to determine...
متن کاملStop-Free Strategies for Traffic Networks: Decentralized On-line Optimization
Traffic management in large networks remains an important challenge in transportation systems. The best approach would be to use existing infrastructure and find a solution to manage the increasing flows of vehicles. Multi-agent systems and autonomous vehicles are today considered as a promising approach to deal with traffic control. In this paper, we propose a two-level decentralized multi-age...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuron
سال: 2003
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(03)00600-7